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The cytosolic tail of the tumor marker protein Trop2 - a structural switch triggered by phosphorylation
Trop2 is a transmembrane signaling glycoprotein upregulated in stem and carcinoma cells. Proliferation-enhancing signaling involves regulated intramembrane proteolytic release of a short cytoplasmic fragment, which is later engaged in a cytosolic signaling complex. We propose that Trop2 function is...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4434849/ https://ncbi.nlm.nih.gov/pubmed/25981199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10324 |
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