Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation

Store-operated Ca(2+) entry (SOCE) is a universal Ca(2+) influx pathway that is important for the function of many cell types. SOCE occurs upon depletion of endoplasmic reticulum (ER) Ca(2+) stores and relies on a complex molecular interplay between the plasma membrane (PM) Ca(2+) channel ORAI1 and...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Maus, Mate, Jairaman, Amit, Stathopulos, Peter B., Muik, Martin, Fahrner, Marc, Weidinger, Carl, Benson, Melina, Fuchs, Sebastian, Ehl, Stephan, Romanin, Christoph, Ikura, Mitsuhiko, Prakriya, Murali, Feske, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434767/
https://ncbi.nlm.nih.gov/pubmed/25918394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418852112
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