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Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.

Biological effects related to cell growth, as well as a role in the pathogenesis of Alzheimer disease, have been ascribed to the beta-amyloid precursor protein (beta-APP). Little is known, however, about the intracellular cascades that mediate these effects. We report that the secreted form of beta-...

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Dettagli Bibliografici
Autori principali: Greenberg, S M, Koo, E H, Selkoe, D J, Qiu, W Q, Kosik, K S
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1994
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC44347/
https://ncbi.nlm.nih.gov/pubmed/8041753
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