Design, Synthesis, and Pharmacological Evaluation of Fused β-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors

[Image: see text] Dipeptidyl peptidase-4 (DPP-4) inhibitors are accepted as a favorable class of agents for the treatment of type 2 diabetes. Herein, a series of fused β-homophenylalanine derivatives as novel DPP-4 inhibitors were designed, synthesized, and evaluated for their inhibitory activities...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Jiang, Tao, Zhou, Yuren, Chen, Zhuxi, Sun, Peng, Zhu, Jianming, Zhang, Qiang, Wang, Zhen, Shao, Qiang, Jiang, Xiangrui, Li, Bo, Chen, Kaixian, Jiang, Hualiang, Wang, Heyao, Zhu, Weiliang, Shen, Jingshan
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434481/
https://ncbi.nlm.nih.gov/pubmed/26005541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00074
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