Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation.

Endothelial thrombomodulin (TM) plays a critical role in hemostasis as a cofactor for thrombin-dependent formation of activated protein C, a potent anticoagulant. Chloramine T, H2O2, or hypochlorous acid generated from H2O2 by myeloperoxidase rapidly destroy 75-90% of TM cofactor activity. Activated...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Glaser, C B, Morser, J, Clarke, J H, Blasko, E, McLean, K, Kuhn, I, Chang, R J, Lin, J H, Vilander, L, Andrews, W H, Light, D R
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 1992
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC443416/
https://ncbi.nlm.nih.gov/pubmed/1334978
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