Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift.

To date, there has been no systematic study of the process of affinity maturation of human antibodies. We therefore sequenced the variable region genes (V genes) of 14 human monoclonal antibodies specific for the erythrocyte Rh(D) alloantigen and determined the germline gene segments of origin and e...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Bye, J M, Carter, C, Cui, Y, Gorick, B D, Songsivilai, S, Winter, G, Hughes-Jones, N C, Marks, J D
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1992
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC443405/
https://ncbi.nlm.nih.gov/pubmed/1469099
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