Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases Lnu(A) and Lnu(D)

One of the main mechanisms of resistance to lincosamide and aminoglycoside antibiotics is their inactivation by O-nucleotidylyltransferases (NTases). Significant sequence variation of lincomycin nucleotidylyltransferase (Lnu) and aminoglycoside nucleotidylyltransferase (ANT) enzymes plus lack of det...

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Pubblicato in:J Mol Biol
Autori principali: Stogios, Peter J., Evdokimova, Elena, Morar, Mariya, Koteva, Kalinka, Wright, Gerard D., Courvalin, Patrice, Savchenko, Alexei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433856/
https://ncbi.nlm.nih.gov/pubmed/25900373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.04.008
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