Classic Ras Proteins Promote Proliferation and Survival Via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells

Neurofibromin, the tumor suppressor encoded by the neurofibromatosis type 1 (NF1) gene, potentially suppresses the activation of H-Ras, N-Ras and K-Ras. However, it is not known whether these classic Ras proteins are hyperactivated in NF1-null nerve sheath tumors, how they contribute to tumorigenesi...

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Detalhes bibliográficos
Publicado no:J Neuropathol Exp Neurol
Main Authors: Brossier, Nicole M., Prechtl, Amanda M., Longo, Jody Fromm, Barnes, Stephen, Wilson, Landon S., Byer, Stephanie J., Brosius, Stephanie N., Carroll, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433624/
https://ncbi.nlm.nih.gov/pubmed/25946318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0000000000000201
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