Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain

[Image: see text] Many intracellular protein–protein interactions are mediated by the phosphorylation of serine, and phosphoserine-containing peptides can inhibit these interactions. However, hydrolysis of the phosphate by phosphatases, and the poor cell permeability associated with phosphorylated p...

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發表在:ACS Chem Biol
Main Authors: White, E. Railey, Sun, Luxin, Ma, Zhong, Beckta, Jason M., Danzig, Brittany A., Hacker, David E., Huie, Melissa, Williams, David C., Edwards, Ross A., Valerie, Kristoffer, Mark Glover, J. N., Hartman, Matthew C. T.
格式: Artigo
語言:Inglês
出版: 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433557/
https://ncbi.nlm.nih.gov/pubmed/25654734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500757u
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