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Multiple factors affect immunogenicity of DNA plasmid HIV vaccines in human clinical trials

Plasmid DNA vaccines have been licensed for use in domesticated animals because of their excellent immunogenicity, but none have yet been licensed for use in humans. Here we report a retrospective analysis of 1218 healthy human volunteers enrolled in 10 phase I clinical trials in which DNA plasmids...

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Detalhes bibliográficos
Publicado no:Vaccine
Main Authors: Jin, Xia, Morgan, Cecilia, Yu, Xuesong, DeRosa, Stephen, Tomaras, Georgia D., Montefiori, David C., Kublin, James, Corey, Larry, Keefer, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433533/
https://ncbi.nlm.nih.gov/pubmed/25820067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2015.03.036
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