Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain

Gene delivery to the central nervous system (CNS) has potential as a means for treating numerous debilitating neurological diseases. Non-viral gene vector platforms are tailorable and can overcome key limitations intrinsic to virus-mediated delivery; however, lack of clinical efficacy with non-viral...

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Bibliografiske detaljer
Udgivet i:Adv Healthc Mater
Main Authors: Mastorakos, Panagiotis, Zhang, Clark, Berry, Sneha, Oh, Yumin, Lee, Seulki, Eberhart, Charles G., Woodworth, Graeme F., Suk, Jung Soo, Hanes, Justin
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433405/
https://ncbi.nlm.nih.gov/pubmed/25761435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adhm.201400800
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