Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2.

Sera from patients with primary biliary cirrhosis (PBC) react with enzymes of the 2-oxo dehydrogenase pathways, particularly PDC-E2. These enzymes are present in all nucleated cells, yet autoimmune damage is confined to biliary epithelial cells. Using a panel of eight mouse monoclonal antibodies and...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Van de Water, J, Turchany, J, Leung, P S, Lake, J, Munoz, S, Surh, C D, Coppel, R, Ansari, A, Nakanuma, Y, Gershwin, M E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443329/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8514873/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116504
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