Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2.

Sera from patients with primary biliary cirrhosis (PBC) react with enzymes of the 2-oxo dehydrogenase pathways, particularly PDC-E2. These enzymes are present in all nucleated cells, yet autoimmune damage is confined to biliary epithelial cells. Using a panel of eight mouse monoclonal antibodies and...

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Hauptverfasser: Van de Water, J, Turchany, J, Leung, P S, Lake, J, Munoz, S, Surh, C D, Coppel, R, Ansari, A, Nakanuma, Y, Gershwin, M E
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1993
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC443329/
https://ncbi.nlm.nih.gov/pubmed/8514873
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