The AIRE -230Y Polymorphism Affects AIRE Transcriptional Activity: Potential Influence on AIRE Function in the Thymus

BACKGROUND: The autoimmune regulator (AIRE) is expressed in the thymus, particularly in thymic medullary epithelial cells (mTECs), and is required for the ectopic expression of a diverse range of peripheral tissue antigens by mTECs, facilitating their ability to perform negative selection of auto-re...

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Udgivet i:PLoS One
Main Authors: Lovewell, Thomas R. J., McDonagh, Andrew J., Messenger, Andrew G., Azzouz, Mimoun, Tazi-Ahnini, Rachid
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4433237/
https://ncbi.nlm.nih.gov/pubmed/25978041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127476
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