Enhancement of macrophage candidacidal activity by interferon-gamma. Increased phagocytosis, killing, and calcium signal mediated by a decreased number of mannose receptors.

In contrast to its macrophage-activating capacity, IFN-gamma downregulates expression of the macrophage mannose receptor (MMR), which mediates uptake of Candida and other microorganisms. We found that IFN-gamma induced a concentration-dependent increase in the capacity of human monocyte-derived macr...

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Pubblicato in:	J Clin Invest
Autori principali:	Maródi, L, Schreiber, S, Anderson, D C, MacDermott, R P, Korchak, H M, Johnston, R B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1993
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443323/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8390485/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116498
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