Chemiexcitation of Melanin Derivatives Induces DNA Photoproducts Long after UV Exposure

Mutations in sunlight-induced melanoma arise from cyclobutane pyrimidine dimers (CPD), DNA photoproducts that are typically created picoseconds after an ultraviolet (UV) photon is absorbed at thymine or cytosine. Here we show that in melanocytes, CPD are generated for >3 hours after exposure to U...

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Veröffentlicht in:Science
Hauptverfasser: Premi, Sanjay, Wallisch, Silvia, Mano, Camila M., Weiner, Adam B., Bacchiocchi, Antonella, Wakamatsu, Kazumasa, Bechara, Etelvino J. H., Halaban, Ruth, Douki, Thierry, Brash, Douglas E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432913/
https://ncbi.nlm.nih.gov/pubmed/25700512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1256022
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