Two distinct mechanisms for bilirubin glucuronide transport by rat bile canalicular membrane vesicles. Demonstration of defective ATP-dependent transport in rats (TR-) with inherited conjugated hyperbilirubinemia.

Bilirubin is conjugated with glucuronic acid in hepatocytes and subsequently secreted in bile. The major conjugate is bilirubin diglucuronide. Using sealed vesicles which are primarily derived from the canalicular (CMV) and sinusoidal (SMV) membrane vesicle domains of the plasma membrane of hepatocy...

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Publicado en:	J Clin Invest
Autores principales:	Nishida, T, Gatmaitan, Z, Roy-Chowdhry, J, Arias, I M
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Clinical Investigation 1992
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443282/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1430236/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116098
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