Two distinct mechanisms for bilirubin glucuronide transport by rat bile canalicular membrane vesicles. Demonstration of defective ATP-dependent transport in rats (TR-) with inherited conjugated hyperbilirubinemia.

Bilirubin is conjugated with glucuronic acid in hepatocytes and subsequently secreted in bile. The major conjugate is bilirubin diglucuronide. Using sealed vesicles which are primarily derived from the canalicular (CMV) and sinusoidal (SMV) membrane vesicle domains of the plasma membrane of hepatocy...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Nishida, T, Gatmaitan, Z, Roy-Chowdhry, J, Arias, I M
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443282/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1430236/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116098
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