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Phosphoproteomic Analysis of Cell-Based Resistance to BRAF Inhibitor Therapy in Melanoma

The treatment of melanoma by targeted inhibition of the mutated kinase BRAF with small molecules only temporarily suppresses metastatic disease. In the face of chemical inhibition tumor plasticity, both innate and adaptive, promotes survival through the biochemical and genetic reconfiguration of cel...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Parker, Robert, Vella, Laura J., Xavier, Dylan, Amirkhani, Ardeshir, Parker, Jimmy, Cebon, Jonathan, Molloy, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432663/
https://ncbi.nlm.nih.gov/pubmed/26029660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2015.00095
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