Caricamento...
Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation
DNMT1 is an important epigenetic regulator that plays a key role in the maintenance of DNA methylation. Here we determined the crystal structure of DNMT1 in complex with USP7 at 2.9 Å resolution. The interaction between the two proteins is primarily mediated by an acidic pocket in USP7 and Lysine re...
Salvato in:
| Pubblicato in: | Nat Commun |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Pub. Group
2015
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4432644/ https://ncbi.nlm.nih.gov/pubmed/25960197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8023 |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !
|