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Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation
DNMT1 is an important epigenetic regulator that plays a key role in the maintenance of DNA methylation. Here we determined the crystal structure of DNMT1 in complex with USP7 at 2.9 Å resolution. The interaction between the two proteins is primarily mediated by an acidic pocket in USP7 and Lysine re...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Pub. Group
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4432644/ https://ncbi.nlm.nih.gov/pubmed/25960197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8023 |
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