Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice

OBJECTIVE: To investigate miR-155 in the SOD1 mouse model and human sporadic and familial amyotrophic lateral sclerosis (ALS). METHODS: Nanostring microRNA, microglia and immune gene profiles, protein mass spectrometry and RNA-seq analyses were measured in spinal cord microglia, splenic monocytes an...

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Publicado no:Ann Neurol
Main Authors: Butovsky, Oleg, Jedrychowski, Mark P., Cialic, Ron, Krasemann, Susanne, Murugaiyan, Gopal, Fanek, Zain, Greco, David J., Wu, Pauline M., Doykan, Camille E., Kiner, Olga, Lawson, Robert J., Frosch, Matthew P., Pochet, Nathalie, Fatimy, Rachid El, Krichevsky, Anna M., Gygi, Steven P., Lassman, Hans, Berry, James, Cudkowicz, Merit E., Weiner, Howard L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432483/
https://ncbi.nlm.nih.gov/pubmed/25381879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24304
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