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The nuclear localization signal of the matrix protein of human immunodeficiency virus type 1 allows the establishment of infection in macrophages and quiescent T lymphocytes.

Lentiviruses, including human immunodeficiency virus type 1 (HIV-1), are unusual among retroviruses in their ability to infect nondividing cells. The matrix proteins of several lentiviruses contain a short stretch of amino acids reminiscent of known nuclear localization signals. In HIV-1, this motif...

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Библиографические подробности
Опубликовано в::Proc Natl Acad Sci U S A
Главные авторы: von Schwedler, U, Kornbluth, R S, Trono, D
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 1994
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Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44324/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8041734/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.15.6992
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