Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2

Cyclooxygenase enzymes (COX-1 and COX-2) catalyze the conversion of arachidonic acid to prostaglandin G(2). The inhibitory activity of rapid, reversible COX inhibitors (ibuprofen, naproxen, mefenamic acid, and lumiracoxib) demonstrated a significant increase in potency and time dependence of inhibit...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Blobaum, Anna L., Xu, Shu, Rowlinson, Scott W., Duggan, Kelsey C., Banerjee, Surajit, Kudalkar, Shalley N., Birmingham, William R., Ghebreselasie, Kebreab, Marnett, Lawrence J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432295/
https://ncbi.nlm.nih.gov/pubmed/25825493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.635987
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