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Blockade of interferon beta, but not interferon alpha, signaling controls persistent viral infection

Although type I interferon (IFN-I) is thought to be beneficial against microbial infections, persistent viral infections are characterized by high interferon signatures suggesting that IFN-I signaling may promote disease pathogenesis. During persistent lymphocytic choriomeningitis virus (LCMV) infec...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Ng, Cherie T., Sullivan, Brian M., Teijaro, John R., Lee, Andrew M., Welch, Megan, Rice, Stephanie, Sheehan, Kathleen C.F., Schreiber, Robert D., Oldstone, Michael B.A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432251/
https://ncbi.nlm.nih.gov/pubmed/25974304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.04.005
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