Bactericidal Monoclonal Antibodies Specific to the Lipopolysaccharide O Antigen from Multidrug-Resistant Escherichia coli Clone ST131-O25b:H4 Elicit Protection in Mice

The Escherichia coli sequence type 131 (ST131)-O25b:H4 clone has spread worldwide and become responsible for a significant proportion of multidrug-resistant extraintestinal infections. We generated humanized monoclonal antibodies (MAbs) that target the lipopolysaccharide O25b antigen conserved withi...

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Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Szijártó, Valéria, Guachalla, Luis M., Visram, Zehra C., Hartl, Katharina, Varga, Cecília, Mirkina, Irina, Zmajkovic, Jakub, Badarau, Adriana, Zauner, Gerhild, Pleban, Clara, Magyarics, Zoltán, Nagy, Eszter, Nagy, Gábor
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432214/
https://ncbi.nlm.nih.gov/pubmed/25779571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04494-14
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