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N-Acetylcysteine Selectively Antagonizes the Activity of Imipenem in Pseudomonas aeruginosa by an OprD-Mediated Mechanism

The modulating effect of N-acetylcysteine (NAC) on the activity of different antibiotics has been studied in Pseudomonas aeruginosa. Our results demonstrate that, in contrast to previous reports, only the activity of imipenem is clearly affected by NAC. MIC and checkerboard determinations indicate t...

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Publicado en:Antimicrob Agents Chemother
Main Authors: Rodríguez-Beltrán, Jerónimo, Cabot, Gabriel, Valencia, Estela Ynés, Costas, Coloma, Bou, German, Oliver, Antonio, Blázquez, Jesús
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432192/
https://ncbi.nlm.nih.gov/pubmed/25801561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00017-15
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