Comparative Efficacies of Tedizolid Phosphate, Vancomycin, and Daptomycin in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Endocarditis

Tedizolid, the active component of the prodrug tedizolid phosphate, is a novel oxazolidinone that is approximately 4 times more active by weight than linezolid against Staphylococcus aureus in vitro. The in vivo efficacy of tedizolid phosphate (15 mg/kg body weight intravenous [i.v.] twice a day [b....

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Publicat a:Antimicrob Agents Chemother
Autors principals: Chan, Liana C., Basuino, Li, Dip, Etyene C., Chambers, Henry F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432129/
https://ncbi.nlm.nih.gov/pubmed/25801564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04376-14
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