Tedizolid as Step-Down Therapy following Daptomycin versus Continuation of Daptomycin against Enterococci and Methicillin- and Vancomycin-Resistant Staphylococcus aureus in a Rat Endocarditis Model

Tedizolid (TZD) and daptomycin (DAP) were assessed in a rat endocarditis model against Enterococcus faecalis, Enterococcus faecium (resistant to vancomycin and ampicillin), and Staphylococcus aureus. As a monotherapy, TZD for 5 days was not effective in a comparison with no-treatment controls, while...

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Udgivet i:Antimicrob Agents Chemother
Main Authors: Singh, Kavindra V., Arias, Cesar A., Murray, Barbara E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179605/
https://ncbi.nlm.nih.gov/pubmed/32122892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02303-19
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