Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans

Overexposure to the essential metal manganese (Mn) can result in an irreversible condition known as manganism that shares similar pathophysiology with Parkinson’s disease (PD), including dopaminergic (DAergic) cell loss that leads to motor and cognitive impairments. However, the mechanisms behind th...

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Detalhes bibliográficos
Publicado no:Metallomics
Main Authors: Chakraborty, Sudipta, Chen, Pan, Bornhorst, Julia, Schwerdtle, Tanja, Schumacher, Fabian, Kleuser, Burkhard, Bowman, Aaron B., Aschner, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431931/
https://ncbi.nlm.nih.gov/pubmed/25769119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5mt00052a
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