Mechanisms underlying abnormal trafficking of malignant progenitors in chronic myelogenous leukemia. Decreased adhesion to stroma and fibronectin but increased adhesion to the basement membrane components laminin and collagen type IV.

We studied the adhesion of primitive and committed progenitors from chronic myelogenous leukemia (CML) and normal bone marrow to stroma and to several extracellular matrix components. In contrast to benign primitive progenitors from CML or normal bone marrow, Ph1-positive primitive progenitors from...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Verfaillie, C M, McCarthy, J B, McGlave, P B
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443164/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1383271/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115985
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