Interferon-alpha restores normal adhesion of chronic myelogenous leukemia hematopoietic progenitors to bone marrow stroma by correcting impaired beta 1 integrin receptor function.

Treatment of chronic myelogenous leukemia (CML) with interferon-alpha frequently results in normalization of peripheral blood counts and, in up to 20% of patients, reestablishment of normal hematopoiesis. We hypothesize that interferon-alpha may restore normal adhesive interactions between CML proge...

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Publicado en:J Clin Invest
Autores principales: Bhatia, R, Wayner, E A, McGlave, P B, Verfaillie, C M
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 1994
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296320/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7518835/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117333
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