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Absence of hereditary p53 mutations in 10 familial leukemia pedigrees.

Germline p53 mutations have been identified in the Li-Fraumeni syndrome but the role of such mutations in familial leukemia is not established. The p53 gene was examined by single-strand conformation polymorphism analysis of exons 4-8 in 10 families with multiple members affected with leukemia. The...

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Hlavní autoři: Felix, C A, D'Amico, D, Mitsudomi, T, Nau, M M, Li, F P, Fraumeni, J F, Cole, D E, McCalla, J, Reaman, G H, Whang-Peng, J
Médium: Artigo
Jazyk:Inglês
Vydáno: 1992
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC443147/
https://ncbi.nlm.nih.gov/pubmed/1644930
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