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Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo.

We reported that glucagon and phenylephrine decrease hepatocyte GSH by inhibiting gamma-glutamylcysteine synthetase (GCS), the rate-limiting enzyme in GSH synthesis (Lu, S.C., J. Kuhlenkamp, C. Garcia-Ruiz, and N. Kaplowitz. 1991. J. Clin. Invest. 88:260-269). In contrast, we have found that insulin...

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Udgivet i:J Clin Invest
Principais autores: Lu, S C, Ge, J L, Kuhlenkamp, J, Kaplowitz, N
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443130/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1353765/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115890
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