Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo.

We reported that glucagon and phenylephrine decrease hepatocyte GSH by inhibiting gamma-glutamylcysteine synthetase (GCS), the rate-limiting enzyme in GSH synthesis (Lu, S.C., J. Kuhlenkamp, C. Garcia-Ruiz, and N. Kaplowitz. 1991. J. Clin. Invest. 88:260-269). In contrast, we have found that insulin...

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Pubblicato in:	J Clin Invest
Autori principali:	Lu, S C, Ge, J L, Kuhlenkamp, J, Kaplowitz, N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443130/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1353765/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115890
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