Differential glucocorticoid metabolism in patients with persistent versus resolving inflammatory arthritis

INTRODUCTION: Impairment in the ability of the inflamed synovium to generate cortisol has been proposed to be a factor in the persistence and severity of inflammatory arthritis. In the inflamed synovium, cortisol is generated from cortisone by the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) e...

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Bibliographic Details
Published in:Arthritis Res Ther
Main Authors: Nanus, Dominika E, Filer, Andrew D, Yeo, Lorraine, Scheel-Toellner, Dagmar, Hardy, Rowan, Lavery, Gareth G, Stewart, Paul M, Buckley, Christopher D, Tomlinson, Jeremy W, Cooper, Mark S, Raza, Karim
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431033/
https://ncbi.nlm.nih.gov/pubmed/25971255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0633-2
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