Epigenetic reprogramming of melanoma cells by vitamin C treatment

BACKGROUND: The loss of 5-hydroxymethylcytosine (5hmC) has been identified as a novel epigenetic hallmark for melanoma. One of the known mechanisms underlying the loss of 5hmC is the decrease in expression of ten-eleven translocation family dioxygenase (TET) genes, which encode enzymes that catalyze...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Gustafson, Christopher B, Yang, Cuixia, Dickson, Kevin M, Shao, Hongwei, Van Booven, Derek, Harbour, J William, Liu, Zhao-Jun, Wang, Gaofeng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430922/
https://ncbi.nlm.nih.gov/pubmed/25977731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0087-z
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