REPTOR and REPTOR-BP regulate organismal metabolism and transcription downstream of TORC1

TORC1 regulates growth and metabolism in part by influencing transcriptional programs. We identify here REPTOR and REPTOR-BP as transcription factors downstream of TORC1, required for ~90% of the transcriptional induction that occurs upon TORC1 inhibition in Drosophila. Thus REPTOR and REPTOR-BP are...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Tiebe, Marcel, Lutz, Marilena, De La Garza, Adriana, Buechling, Tina, Boutros, Michael, Teleman, Aurelio A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430829/
https://ncbi.nlm.nih.gov/pubmed/25920570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.03.013
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