Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells

The splicing factor SF3B1 is the most commonly mutated gene in the myelodysplastic syndrome (MDS), particularly in patients with refractory anemia with ring sideroblasts (RARS). We investigated the functional effects of SF3B1 disruption in myeloid cell lines: SF3B1 knockdown resulted in growth inhib...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Dolatshad, H, Pellagatti, A, Fernandez-Mercado, M, Yip, B H, Malcovati, L, Attwood, M, Przychodzen, B, Sahgal, N, Kanapin, A A, Lockstone, H, Scifo, L, Vandenberghe, P, Papaemmanuil, E, Smith, C W J, Campbell, P J, Ogawa, S, Maciejewski, J P, Cazzola, M, Savage, K I, Boultwood, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430703/
https://ncbi.nlm.nih.gov/pubmed/25428262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.331
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