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Severe Insulin Resistance Alters Metabolism in Mesenchymal Progenitor Cells
Donohue syndrome (DS) is characterized by severe insulin resistance due to mutations in the insulin receptor (INSR) gene. To identify molecular defects contributing to metabolic dysregulation in DS in the undifferentiated state, we generated mesenchymal progenitor cells (MPCs) from induced pluripote...
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| Published in: | Endocrinology |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Endocrine Society
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4430624/ https://ncbi.nlm.nih.gov/pubmed/25811318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1403 |
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