Severe Insulin Resistance Alters Metabolism in Mesenchymal Progenitor Cells

Donohue syndrome (DS) is characterized by severe insulin resistance due to mutations in the insulin receptor (INSR) gene. To identify molecular defects contributing to metabolic dysregulation in DS in the undifferentiated state, we generated mesenchymal progenitor cells (MPCs) from induced pluripote...

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Bibliographic Details
Published in:Endocrinology
Main Authors: Balhara, Bharti, Burkart, Alison, Topcu, Vehap, Lee, Youn-Kyoung, Cowan, Chad, Kahn, C. Ronald, Patti, Mary-Elizabeth
Format: Artigo
Language:Inglês
Published: Endocrine Society 2015
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430624/
https://ncbi.nlm.nih.gov/pubmed/25811318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1403
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