Severe Insulin Resistance Alters Metabolism in Mesenchymal Progenitor Cells

Donohue syndrome (DS) is characterized by severe insulin resistance due to mutations in the insulin receptor (INSR) gene. To identify molecular defects contributing to metabolic dysregulation in DS in the undifferentiated state, we generated mesenchymal progenitor cells (MPCs) from induced pluripote...

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Опубликовано в: :Endocrinology
Главные авторы: Balhara, Bharti, Burkart, Alison, Topcu, Vehap, Lee, Youn-Kyoung, Cowan, Chad, Kahn, C. Ronald, Patti, Mary-Elizabeth
Формат: Artigo
Язык:Inglês
Опубликовано: Endocrine Society 2015
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Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430624/
https://ncbi.nlm.nih.gov/pubmed/25811318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1403
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