Genetic Insulin Resistance Is a Potent Regulator of Gene Expression and Proliferation in Human iPS Cells

Insulin resistance is central to diabetes and metabolic syndrome. To define the consequences of genetic insulin resistance distinct from those secondary to cellular differentiation or in vivo regulation, we generated induced pluripotent stem cells (iPSCs) from individuals with insulin receptor mutat...

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Vydáno v:Diabetes
Hlavní autoři: Iovino, Salvatore, Burkart, Alison M., Kriauciunas, Kristina, Warren, Laura, Hughes, Katelyn J., Molla, Michael, Lee, Youn-Kyoung, Patti, Mary-Elizabeth, Kahn, C. Ronald
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2014
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238001/
https://ncbi.nlm.nih.gov/pubmed/25059784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0109
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