Inbreeding among Caribbean Hispanics from the Dominican Republic and the Effects on the Risk of Alzheimer's Disease

BACKGROUND: Inbreeding can be associated with a modification in disease risk due to excess homozygosity of recessive alleles impacting a wide range of phenotypes. We estimated the inbreeding coefficient in Caribbean Hispanics and examined its effects on risk of late-onset Alzheimer's Disease (L...

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Bibliographic Details
Published in:Genet Med
Main Authors: Vardarajan, BN, Schaid, D, Reitz, C, Lantigua, R, Medrano, M, Jiménez-Velázquez, IZ, Lee, JH, Ghani, M, Rogaeva, E, St George-Hyslop, P, Mayeux, R
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430451/
https://ncbi.nlm.nih.gov/pubmed/25394174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gim.2014.161
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