Definition of a discontinuous immunodominant epitope at the NH2 terminus of the La/SS-B ribonucleoprotein autoantigen.

High-titer IgG autoantibodies to the La/SS-B ribonucleoprotein (RNP) are a hallmark of patients with primary Sjogren's syndrome. Anti-La/SS-B-positive human sera bind to multiple epitopes on recombinant La/SS-B, although the initial response is against an immunodominant epitope within the first...

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Bibliographische Detailangaben
Hauptverfasser: McNeilage, L J, Umapathysivam, K, Macmillan, E, Guidolin, A, Whittingham, S, Gordon, T
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1992
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC443042/
https://ncbi.nlm.nih.gov/pubmed/1373741
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