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p185, an Immunodominant Epitope, Is an Autoantigen Mimotope

An immunodominant peptide (p185(378–394)) derived from the c-erbB2 gene product, was recognized by an anti-DNA antibody, B3, and importantly by two classical DNA-binding proteins, Tgo polymerase and Pa-UDG. These reactivities were inhibited by DNA, confirming that the peptide mimicked DNA. BALB/c mi...

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Detalhes bibliográficos
Main Authors: Kumar, Sanjeev, Hinks, John A., Maman, Joseph, Ravirajan, Chelliah T., Pearl, Laurence H., Isenberg, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138268/
https://ncbi.nlm.nih.gov/pubmed/21566138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.224303
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