Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators

Our recent studies in SKH-1 hairless mice have demonstrated that topical exposure to nitrogen mustard (NM), an analog of sulfur mustard (SM), triggers the inflammatory response, microvesication and apoptotic cell death. Here, we sought to identify the mechanism/s involved in these NM-induced injury...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Toxicol Lett
Main Authors: Kumar, Dileep, Tewari-Singh, Neera, Agarwal, Chapla, Jain, Anil K., Inturi, Swetha, Kant, Rama, White, Carl W., Agarwal, Rajesh
Formato: Artigo
Idioma:Inglês
Publicado: 2015
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430414/
https://ncbi.nlm.nih.gov/pubmed/25891025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2015.04.006
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares