Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by cis-diamminedichloroplatinum(II).

We have investigated the effect of cis-diamminedichloroplatinum(II) (CDDP) on signal transduction pathways. CDDP treatment did not cause any change in the binding of [3H]-phorbol dibutyrate to PC-9 (human lung adenocarcinoma cell line) cells, a measure of protein kinase C activation. However, 2-h CD...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Nishio, K, Sugimoto, Y, Fujiwara, Y, Ohmori, T, Morikage, T, Takeda, Y, Ohata, M, Saijo, N
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1992
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443038/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1569201/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115758
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