Phospholipase C-mediated hydrolysis of phosphatidylcholine is activated by cis-diamminedichloroplatinum(II).

We have investigated the effect of cis-diamminedichloroplatinum(II) (CDDP) on signal transduction pathways. CDDP treatment did not cause any change in the binding of [3H]-phorbol dibutyrate to PC-9 (human lung adenocarcinoma cell line) cells, a measure of protein kinase C activation. However, 2-h CD...

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Detalhes bibliográficos
Main Authors: Nishio, K, Sugimoto, Y, Fujiwara, Y, Ohmori, T, Morikage, T, Takeda, Y, Ohata, M, Saijo, N
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC443038/
https://ncbi.nlm.nih.gov/pubmed/1569201
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