Identification of a thermolabile component of the human neutrophil NADPH oxidase. A model for chronic granulomatous disease caused by deficiency of the p67-phox cytosolic component.

Mild heating of human neutrophils inactivates the respiratory burst oxidase, producing a defect in superoxide production and bacterial killing comparable to that seen in patients afflicted with chronic granulomatous disease (CGD). We have now investigated the mechanism and specificity of this inacti...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Erickson, R W, Malawista, S E, Garrett, M C, Van Blaricom, G, Leto, T L, Curnutte, J T
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1992
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443033/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1314852/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115753
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!