Identification of a thermolabile component of the human neutrophil NADPH oxidase. A model for chronic granulomatous disease caused by deficiency of the p67-phox cytosolic component.

Mild heating of human neutrophils inactivates the respiratory burst oxidase, producing a defect in superoxide production and bacterial killing comparable to that seen in patients afflicted with chronic granulomatous disease (CGD). We have now investigated the mechanism and specificity of this inacti...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Erickson, R W, Malawista, S E, Garrett, M C, Van Blaricom, G, Leto, T L, Curnutte, J T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC443033/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1314852/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115753
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