Identification of a thermolabile component of the human neutrophil NADPH oxidase. A model for chronic granulomatous disease caused by deficiency of the p67-phox cytosolic component.

Mild heating of human neutrophils inactivates the respiratory burst oxidase, producing a defect in superoxide production and bacterial killing comparable to that seen in patients afflicted with chronic granulomatous disease (CGD). We have now investigated the mechanism and specificity of this inacti...

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Bibliographic Details
Main Authors: Erickson, R W, Malawista, S E, Garrett, M C, Van Blaricom, G, Leto, T L, Curnutte, J T
Format: Artigo
Language:Inglês
Published: 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC443033/
https://ncbi.nlm.nih.gov/pubmed/1314852
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