Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing

Undetected and untreated, low-levels of drug resistant (DR) subpopulations in clinical Mycobacterium tuberculosis (Mtb) infections may lead to development of DR-tuberculosis, potentially resulting in treatment failure. Current phenotypic DR susceptibility testing has a theoretical potential for 1% s...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Colman, Rebecca E., Schupp, James M., Hicks, Nathan D., Smith, David E., Buchhagen, Jordan L., Valafar, Faramarz, Crudu, Valeriu, Romancenco, Elena, Noroc, Ecaterina, Jackson, Lynn, Catanzaro, Donald G., Rodwell, Timothy C., Catanzaro, Antonino, Keim, Paul, Engelthaler, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430321/
https://ncbi.nlm.nih.gov/pubmed/25970423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126626
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