Detection of Low-Level Mixed-Population Drug Resistance in Mycobacterium tuberculosis Using High Fidelity Amplicon Sequencing

Undetected and untreated, low-levels of drug resistant (DR) subpopulations in clinical Mycobacterium tuberculosis (Mtb) infections may lead to development of DR-tuberculosis, potentially resulting in treatment failure. Current phenotypic DR susceptibility testing has a theoretical potential for 1% s...

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Veröffentlicht in:PLoS One
Hauptverfasser: Colman, Rebecca E., Schupp, James M., Hicks, Nathan D., Smith, David E., Buchhagen, Jordan L., Valafar, Faramarz, Crudu, Valeriu, Romancenco, Elena, Noroc, Ecaterina, Jackson, Lynn, Catanzaro, Donald G., Rodwell, Timothy C., Catanzaro, Antonino, Keim, Paul, Engelthaler, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430321/
https://ncbi.nlm.nih.gov/pubmed/25970423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0126626
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